abstract：:Most changes of tumor suppressor p53 and its pathway involve a protein with prolonged half-life that permits immunohistochemical detection. The goal of this study was to compare the prognostic relevance of five different p53 antibodies in primary soft-tissue sarcomas (STS) with known p53 mutation status, using a multi...

journal_title：Journal of cancer research and clinical oncology

authors： Würl P,Taubert H,Meye A,Berger D,Lautenschläger C,Holzhausen HJ,Schmidt H,Kalthoff H,Rath FW,Dralle H

更新日期：1997-01-01 00:00:00

abstract：:A novel butyric acid derivative, pivaloyloxymethyl butyrate, AN-9, was previously shown to be a potent differentiating agent. AN-9 exerts a significant anticancer activity in vitro and in vivo. In all the activities examined, AN-9 was more potent than butyric acid. Here we show that AN-9 and butyric acid induce cell d...

journal_title：Journal of cancer research and clinical oncology

authors： Zimra Y,Wasserman L,Maron L,Shaklai M,Nudelman A,Rephaeli A

更新日期：1997-01-01 00:00:00

abstract：:The two hormone analogues octreotide and goserelin have been shown to decelerate growth of human pancreatic cancer in vitro and in vivo. The objective of this pilot study was to investigate the efficacy and toxicity of the combination of these two agents in patients with advanced pancreatic cancer. Octreotide was inje...

journal_title：Journal of cancer research and clinical oncology

authors： Fazeny B,Baur M,Prohaska M,Hudec M,Kremnitzer M,Meryn S,Huber H,Grunt T,Tuchmann A,Dittrich C

更新日期：1997-01-01 00:00:00

abstract：:The relation between the intracellular glutathione (GSH) concentration and hydrogen-peroxide(H2O2)-induced cytotoxicity was investigated. The intracellular GSH concentration in human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines was one or two orders of magnitude higher than that in a human myelogenous leuke...

journal_title：Journal of cancer research and clinical oncology

authors： Iida M,Sunaga S,Hirota N,Kuribayashi N,Sakagami H,Takeda M,Matsumoto K

更新日期：1997-01-01 00:00:00

abstract：:P-glycoprotein (P-gp), a cell membrane protein, has been found in multidrug-resistant cancer cells. A total of 104 smears from patients with breast-cancer-associated pleural effusions and ovarian-cancer-related peritoneal effusions were studied for P-gp with the antibody C-219 and the avidin-biotin-immunoperoxidase me...

journal_title：Journal of cancer research and clinical oncology

authors： Athanassiadou P,Athanassiades P,Petrakakou E,Zerva C,Mavrikakis M

更新日期：1997-01-01 00:00:00

abstract：:Expression of the glutathione S-transferase (GST) subclasses alpha, mu and pi was investigated immunohistochemically in 20 normal or hyperplastic mesothelium and in 57 malignant mesothelioma cases. These results were correlated with survival and also with P-170 glycoprotein expression. Nearly all the non-neoplastic me...

journal_title：Journal of cancer research and clinical oncology

authors： Segers K,Kumar-Singh S,Weyler J,Bogers J,Ramael M,Van Meerbeeck J,Van Marck E

更新日期：1996-01-01 00:00:00

abstract：:To investigate multidrug-resistance gene (MDR1) promoter efficacy and drug inducibility in cells with different multidrug-resistance phenotypes, multidrug-resistant HCT15 and drug-sensitive KM12 human colon carcinoma cell lines were transfected with constructs incorporating the chloramphenicol acetyltransferase (CAT) ...

journal_title：Journal of cancer research and clinical oncology

authors： Stein U,Walther W,Shoemaker RH

更新日期：1996-01-01 00:00:00

abstract：:The chemosensitizing potency of dexniguldipine hydrochloride (B8509-035) on epidoxorubicin was assessed in a multidrug-resistant (MDR) tumour model, the intrinsic MDR rat colon carcinoma CC531. In vitro in the sulphorhodamine B cell-viability assay the cytotoxicity of epidoxorubicin was increased approximately 15-fold...

journal_title：Journal of cancer research and clinical oncology

authors： Van de Vrie W,Schellens JH,Loss WJ,Kolker HJ,Verwey J,Stoter G,Durante NM,Eggermont AM

更新日期：1996-01-01 00:00:00

abstract：:The precise place of local estrogen production in mammary cancer is still controversial. In this investigation localization of aromatase (the key enzyme of estrogen biosynthesis) was studied in breast cancer tissue by immunohistochemical method using polyclonal rabbit antibodies. The cytoplasmic staining was found in ...

journal_title：Journal of cancer research and clinical oncology

authors： Berstein LM,Larionov AA,Kyshtoobaeva ASh,Pozharisski KM,Semiglazov VF,Ivanova OA

更新日期：1996-01-01 00:00:00

abstract：:The nuclear DNA content (DNA ploidy) level was determined in a series of 83 human brain metastases, for which 35 complete clinical follow-ups were available. The DNA ploidy level determination was carried out by means of DNA histogram types. The results show that certain brain metastases were diploid, while others exh...

journal_title：Journal of cancer research and clinical oncology

authors： Kiss R,Rorive S,Camby I,Pasteels JL,Brotchi J,Salmon I

更新日期：1996-01-01 00:00:00

abstract：:The antigen complex A60 of Mycobacterium bovis bacillus Calmette-Guérin protected mice against experimental tuberculous infection, and prevented cancer development after challenge with EMT 6 cells. Although humoral and cellular immune reactions elicited by A60 in vivo remained unaffected in cases of tumor rejection, t...

journal_title：Journal of cancer research and clinical oncology

authors： Maes H,Cocito C

更新日期：1996-01-01 00:00:00

abstract：:According to a "two-hit" model, dominantly inherited predisposition to cancer entails a germline mutation, while tumorigenesis requires a second, somatic, mutation. Non-hereditary cancer of the same type requires the same two hits, but both are somatic. The original tumor used in this model, retinoblastoma, involves m...

journal_title：Journal of cancer research and clinical oncology

authors： Knudson AG

更新日期：1996-01-01 00:00:00

abstract：:General principles for anticancer drug development include traditional drug-screening methods in biological test systems. Today, testing of a drug in a panel of selected human tumor xenografts in mice is assumed to have the best predictive value for clinical efficacy. Chemical modification of well-known antitumor drug...

journal_title：Journal of cancer research and clinical oncology

authors： Unger C

更新日期：1996-01-01 00:00:00

abstract：:For therapeutic purposes, two chimeric DNA/RNA hammerhead ribozymes were synthesized to cleave AML1/MTG8, the t(8;21)-associated fusion mRNA of acute myeloid leukemia. One ribozyme, A/MRZ-1, recognizes the area adjacent to the fusion point between AML1 and MTG8, and cleaves six bases downstream from this point. The ot...

journal_title：Journal of cancer research and clinical oncology

authors： Kozu T,Sueoka E,Okabe S,Sueoka N,Komori A,Fujiki H

更新日期：1996-01-01 00:00:00

abstract：:A series of 191 female breast carcinomas (with long-term follow-up) were analysed immunohistochemically (with a monoclonal MIB1 antibody) for Ki-67 (a proliferation marker) expression with special reference to well-established prognostic factors and patient survival. Expression of Ki-67 was directly related to the S-p...

journal_title：Journal of cancer research and clinical oncology

authors： Pietiläinen T,Lipponen P,Aaltomaa S,Eskelinen M,Kosma VM,Syrjänen K

更新日期：1996-01-01 00:00:00

abstract：:The primary objective of this study was to determine the response rate of patients with metastatic colorectal cancer to combined therapy with 5-fluorouracil (5-FU), leucovorin, and intravenous azidothymidine (AZT), a thymidine nucleoside analog. By itself, AZT has limited antineoplastic efficacy. However, experimental...

journal_title：Journal of cancer research and clinical oncology

authors： Clark J,Sikov W,Cummings F,Browne M,Akerley W,Wanebo H,Weitberg A,Kennedy T,Cole B,Bigley J,Beitz J,Darnowski J

更新日期：1996-01-01 00:00:00

abstract：:Resistance to cytotoxic chemotherapy is a major problem in the management of patients with metastatic breast cancer. Various data suggest P-glycoprotein-associated multidrug resistance (MDR) to be a relevant resistance mechanism in this tumor. The purpose of this study was to evaluate feasibility and activity of combi...

journal_title：Journal of cancer research and clinical oncology

authors： Thürlimann B,Kröger N,Greiner J,Mross K,Schüller J,Schernhammer E,Schumacher K,Gastl G,Hartlapp J,Kupper H

更新日期：1995-01-01 00:00:00

abstract：:Modulation of 5-fluorouracil (5-FU) is currently being investigated in advanced colorectal cancer. In an attempt to improve the results obtainable for the association of 5-FU and leucovorin, we decided to add cisplatin to 5-FU and (6S)-leucovorin (S-LV) after disease progression. The hypothesis was that a pharmacologi...

journal_title：Journal of cancer research and clinical oncology

authors： Cassano A,Pozzo C,Corsi DC,Fontana T,Noviello MR,Astone A,Barone C

更新日期：1995-01-01 00:00:00

abstract：:Circulating blood cell counts, serum cortisol, proteins, alkaline phosphatase, carcinoembryonic antigen and CA15.3 displayed significant circadian rhythms in a group of 13 women with metastatic breast cancer. Statistical significance (P < 0.05) was assessed with both analysis of variance and cosinor analysis. All pati...

journal_title：Journal of cancer research and clinical oncology

authors： Touitou Y,Lévi F,Bogdan A,Benavides M,Bailleul F,Misset JL

更新日期：1995-01-01 00:00:00

abstract：:Induction of gene transcription in response to extracellular stimuli constitutes an essential aspect of host defense mechanisms. Interferons (IFN) are families of cytokines that have been discovered and extensively characterized in the context of host defense against viral infections. In elucidating the mechanism of t...

journal_title：Journal of cancer research and clinical oncology

authors： Taniguchi T,Harada H,Lamphier M

更新日期：1995-01-01 00:00:00

abstract：:Adenocarcinomas of the lungs show a variable histology. We have subclassified such lesions into five cell types: hobnail, columnar, polygonal, mixed and goblet cell types, and investigated their relationships with K-ras mutations. Codons 12, 13 and 61 of the K-ras gene in 120 surgically resected pulmonary adenocarcino...

journal_title：Journal of cancer research and clinical oncology

authors： Tsuchiya E,Furuta R,Wada N,Nakagawa K,Ishikawa Y,Kawabuchi B,Nakamura Y,Sugano H

更新日期：1995-01-01 00:00:00

abstract：:Carboplatin and interferon beta (IFN beta) were tested alone and in combination for their antiproliferative activity on the human melanoma cell line SK-MEL 28 in vitro. Cells were incubated for 4 days in the presence of carboplatin (0.1 mM and 0.1 microM) and interferon beta (5 pM and 5 nM) and cell growth inhibition ...

journal_title：Journal of cancer research and clinical oncology

authors： Hübner B,Eckert K,Garbe C,Maurer HR

更新日期：1995-01-01 00:00:00

abstract：:It was shown that cyclopeptolide SDZ 214-103 (10 microM) is more active in rhodamine-123 accumulation in actinomycin-D-resistant human lymphoma cells CCRF/ACTD400 than cyclosporin A (10 microM), but equipotent in the doxorubicin-resistant Friend erythroleukemia cell line F4-6/ADR. In F4-6/ADR cells, the 3-(4,5-dimethy...

journal_title：Journal of cancer research and clinical oncology

authors： Schwabe K,Steinheider G,Lawen A,Traber R,Hildebrandt A

更新日期：1995-01-01 00:00:00

abstract：:To investigate further the presence of an autocrine proliferative loop involving gastrin in colorectal carcinomas and to clarify the receptor responsible, 102 human colorectal carcinomas and 10 hepatic metastases were investigated for the expression of the genes encoding gastrin, the gastrin/CCK-B receptor and the gas...

journal_title：Journal of cancer research and clinical oncology

authors： Imdahl A,Mantamadiotis T,Eggstein S,Farthmann EH,Baldwin GS

更新日期：1995-01-01 00:00:00

abstract：:Point mutations occurring at codon 201 of the gene coding for the alpha subunit of the stimulatory G protein impair intrinsic GTPase activity and lead to a constitutive activation of adenylate cyclase. We have examined thyroid follicular and papillary carcinomas and follicular adenomas and found samples that bear this...

journal_title：Journal of cancer research and clinical oncology

authors： Gorelov VN,Dumon K,Barteneva NS,Palm D,Röher HD,Goretzki PE

更新日期：1995-01-01 00:00:00

abstract：:The human histiocytic cell line U 937, which expresses a number of monocyte markers and properties, was investigated with regard to its ability to be activated for NO and tumor necrosis factor (TNF) release after treatment with alkylphosphocholines (APC) and APC liposomes. Using APC multilamellar vesicles (MLV) a clea...

journal_title：Journal of cancer research and clinical oncology

authors： Eue I,Zeisig R,Arndt D

更新日期：1995-01-01 00:00:00

abstract：:This article summarizes the various current uses of cytokines, and bone marrow and peripheral blood stem cell transplantation for cancer treatment. Interferons, interleukin-2 and hematopoietic growth factors are extensively used for the treatment of hematopoietic as well as nonhematopoietic malignancies, either as the...

journal_title：Journal of cancer research and clinical oncology

authors： Takaku F

更新日期：1995-01-01 00:00:00

abstract：:Disseminated histiocytosis X with cutaneous and lymph node involvement was diagnosed in a 25-year-old women. The diagnosis was established on the basis of a positive cell-surface staining with OKT 6 and typical signs on electron microscopy. Both the specific skin rash and lymph node swelling completely disappeared dur...

journal_title：Journal of cancer research and clinical oncology

authors： Scherbaum WA,Seif FJ

更新日期：1995-01-01 00:00:00

abstract：:Establishment of new tumor cell lines is an important first step for biological studies of tumor cells. High success rates in establishing retinoblastoma cell lines have been reported when feeder-layer culture but not liquid-culture techniques were used. Liquid culture is, however, essential for studies in which feede...

journal_title：Journal of cancer research and clinical oncology

authors： Inomata M,Kaneko A,Saijo N,Tokura S

更新日期：1994-01-01 00:00:00

abstract：:In this summary, J. Konietzko (Mainz) stressed the exceptional position of occupational cancer, which is due to the long latent period between exposure to specific carcinogens and cancer manifestation. Obviously, this long latent period of years to decades poses problems in the search for the etiology of occupational ...

journal_title：Journal of cancer research and clinical oncology

authors： Berger MR

更新日期：1994-01-01 00:00:00

abstract：:Rat 13672 mammary carcinoma tumors were grown subcutaneously in the hind legs of female Fischer 344 rats to a volume of about 1 cm3. Tumor oxygenation was measured using an Eppendorf PO2 histograph. Tumor oxygen measurements were made under four conditions: (a) normal air breathing, (b) carbogen breathing, (c) after i...

journal_title：Journal of cancer research and clinical oncology

authors： Teicher BA,Sotomayor EA,Dupuis NP,Kusumoto T,Menon K

更新日期：1994-01-01 00:00:00

abstract：:A series of 202 breast cancer biopsy specimens were analysed immunohistochemically for collagen IV to demonstrate basement membrane (BM) structures and blood vessels within tumour tissue. Integrity of the BM was graded into four categories and the number of vascular channels per square millimetre of tumour tissue were...

journal_title：Journal of cancer research and clinical oncology

authors： Lipponen P,Ji H,Aaltomaa S,Syrjänen K

更新日期：1994-01-01 00:00:00

abstract：:A phase II trial of etoposide (100 mg/m2) on days 4, 5, 6, doxorubicin (Adriamycin, 20 mg/m2) on days 1, 7, and cisplatin (30 mg/m2) on days 2, 8 (EAP) was carried out in order to reduce toxicity associated with a full-dose EAP regimen for advanced and/or metastatic gastric adenocarcinoma. Out of 21 evaluable patients...

journal_title：Journal of cancer research and clinical oncology

authors： Gebbia V,Valenza R,Testa A,Sciume C,Longo A,Cipolla C,Borsellino N,Leo P,Latteri M,Florena M

更新日期：1994-01-01 00:00:00

abstract：:Coumarin (1,2-benzopyrone) is a natural substance that has shown antitumor activity in vivo. The major human metabolite of coumarin, 7-hydroxycoumarin (7-HC), is the active form of the drug. While the exact mechanism(s) of action of coumarin is unknown, it has been shown previously that this drug possesses immunomodul...

journal_title：Journal of cancer research and clinical oncology

authors： Marshall ME,Kervin K,Benefield C,Umerani A,Albainy-Jenei S,Zhao Q,Khazaeli MB

更新日期：1994-01-01 00:00:00

abstract：:The long-term prognosis of surgery for hepatocellular carcinoma (HCC) is not yet satisfactory, the main reason being the high recurrence rate. The authors report the results of a long-term follow-up of 308 patients with HCC who became alpha-fetoprotein-(AFP)-negative after resection between 1975 and 1991. By March 199...

journal_title：Journal of cancer research and clinical oncology

authors： Zhou XD,Tang ZY,Yu YQ,Yang BH,Lu JZ,Lin ZY,Ma ZC,Zhang BH

更新日期：1994-01-01 00:00:00

abstract：:The dihydropyridine, dexniguldipine hydrochloride (B859-35), has shown therapeutic activity in experimentally induced neuroendocrine hamster lung tumors and demonstrated antiproliferative effects in a mammary cancer cell line via inhibition of Ca2+ calmodulin. Studies in NIH 3T3 fibroblasts have provided evidence that...

journal_title：Journal of cancer research and clinical oncology

authors： Schuller HM,Orloff M,Reznik GK

更新日期：1994-01-01 00:00:00

abstract：:The proliferative activity in 70 cases of soft-tissue tumours was estimated immunohistochemically using the monoclonal antibody PC-10, which recognizes proliferating-cell nuclear antigen (PCNA) in paraffin sections. The PCNA index (i.e. the percentage of positive neoplastic nuclei) and to a lesser degree the PCNA coun...

journal_title：Journal of cancer research and clinical oncology

authors： Korkolopoulou P,Christodoulou P,Papanikolaou A,Tsenga A,Thomas-Tsagli E

更新日期：1994-01-01 00:00:00

abstract：:Recently a new proto-oncogene, the murine double-minute 2 (MDM2), has been described. MDM2 becomes oncogenic due to amplification and overexpression. Among other proto-oncogenes MDM2 becomes interesting since MDM2 protein can associate with both mutant and wild type p53 tumor suppressor gene products and thus inhibit ...

journal_title：Journal of cancer research and clinical oncology

authors： Wiethege T,Voss B,Müller KM

更新日期：1994-01-01 00:00:00

abstract：:Multicellular tumor spheroids (MCTS) grown from the bladder cancer cell line RT112 and from the prostate cancer cell line PCA were exposed to 200 or 800 electromagnetically generated focused ultrasound shock waves. RT112 cells showed a distinct but transient decrease in proliferation whereas the effect of PCA cells wa...

journal_title：Journal of cancer research and clinical oncology

authors： Nicolai H,Steinbach P,Knuechel-Clarke R,Grimm D,Roessler W,Wieland WF,Hofstaedter F

更新日期：1994-01-01 00:00:00

abstract：:The association of Epstein-Barr virus (EBV) with gastric medullary carcinoma with lymphoid infiltration (GMCL) was investigated. The presence of GMCL exhibited a 2/1 male-to-female ratio and a 1/2 early-to-advanced cancer ratio, predominantly located in the cardia and corpus of the stomach (90%). The presence of EBV D...

journal_title：Journal of cancer research and clinical oncology

authors： Takano Y,Kato Y,Sugano H

更新日期：1994-01-01 00:00:00